Masimo Debuts 2012 Radical-7® at World Congress of Anaesthesiologists

Irvine, California – March 26, 2012 – Masimo (NASDAQ: MASI), the inventor of rainbow Pulse CO-Oximetry™, rainbow Acoustic Monitoring™, and Masimo SET® Measure-Through Motion and Low Perfusion pulse oximetry, debuted its 2012 Radical-7 monitor at the 15th World Congress of Anaesthesiologistsconference in Buenos Aires, Argentina, March 25-30, 2012.

Automatic rotational screen for either horizontal or vertical display

Once again raising the technologic bar, the 2012 Radical-7 leverages Masimo's breakthrough noninvasive measurements with breakthrough functionality designed to automate the process of care and enable clinicians to instantly adapt to changing monitoring needs in individual patients and care areas.

The 2012 Radical-7's upgradeable rainbow® SET platform features noninvasive and continuous monitoring of:

• Blood constituents that previously required invasive or complicated procedures, including total hemoglobin (SpHb®), oxygen content (SpOC™), pleth variability index (PVI®), carboxyhemoglobin (SpCO®), and methemoglobin (SpMet®)
• Masimo SET measure-through motion and low perfusion pulse oximetry for oxygen saturation (SpO2), pulse rate, and perfusion index
• Respiration rate through a novel acoustic sensor (RRa™) clinically shown to be as accurate if not more than capnography for respiration rate, or even through the plethysmograph waveform (RRp™), though less reliable than RRa.

Detachable, battery-operated, wireless handheld or wearable device to facilitate untethered monitoring during transport and ambulation with built-in wi-fi.

The 2012 Radical-7 is rainbow® centric, with its intuitive, gesture-control, touch screen that allows SpHb, SpOC, SpCO, SpMet, and RRa to be viewed as prominently as SpO2 and pulse rate. The 2012 Radical-7 offers exceptionally easy operation and instant adaptability to change displays and settings on the fly. With a quick touch, drag, and drop, clinicians can move any parameter to and from center and bottom of the display, never losing track of any vital signs. The instant-trend feature provides the ability to view one or two parameters at once and with a simple finger gesture, clinicians can move, expand, or collapse parameter trends for real-time analysis. Standard wireless connectivity from integrated 802.11 and Bluetooth® technology in the handheld Radical-7 keeps patients connected even while they are ambulating to enable clinician notification and automate charting and enable meaningful use of electronic health record systems.

The 2012 Radical-7 includes a variety of features designed to simplify the clinician's life. Adaptive Threshold Alarm™, helps clinicians manage nuisance alarms and reduces the time required to set patient-specific alarms by automatically adjusting the audible alarm to the patient's baseline. In Vivo Adjustment™, allows clinicians to adjust the noninvasive measurements to the specific patient and laboratory reference device they use for invasive blood testing. These capabilities received the CE Mark in 2011 and are pending FDA 510(k) clearance.

The Radical-7 offers unprecedented versatility in multiple care areas with its automatic rotational screen for either horizontal or vertical display and three-in-one capability to be used as: 1) a standalone device for bedside monitoring; 2) a detachable, battery-operated wireless device handheld or wearable device to facilitate untethered monitoring during transport and ambulation; and 3) a multiparameter monitoring interface via SatShare®, allowing hospitals to seamlessly implement rainbow® measurement capabilities in the Radical-7 display while automatically sending the Radical-7's Masimo SET pulse oximetry measurements for display on the multiparameter monitor.

Intuitive, gesture-control, touchscreen for exceptionally easy operation and instantly adaptable functionality.

The 2012 Radical-7 continues to provide respiration rate with unprecedented ease and reliability via revolutionary rainbow Acoustic Monitoring™. The Radical-7 now also includes the ability to measure respiration rate from the plethysmograph waveform (RRp™), enabling monitoring of breathing status from a standard Masimo SET pulse oximetry or rainbow® Pulse CO-Oximetry sensor in all patients in whom those sensors are indicated. The RRp measurement received the CE Mark in March 2011 and has been available on the Rad-87® monitor, but this is the first time it is available on the Radical-7 in CE Mark countries. The RRp measurement is determined by the variations in the plethysmograph waveform due to respiration, although the measurement is not possible in all patients or conditions. For patients in whom reliable and continuous respiration rate monitoring is required, Masimo's acoustic respiration rate (RRa) measurement provides accurate and patient-tolerant monitoring of breathing through an acoustic sensor placed on the neck. The Radical-7's RRa measurement also provides an important visual indication of breathing through the displayed acoustic waveform.

The 2012 Radical-7 unleashes the power of rainbow® to help empower clinicians to improve patient outcomes and reduce the cost of care in multiple ways, such as reducing blood transfusion-related costs and detecting bleeding earlier with SpHb, optimizing fluid management with PVI, and enabling reliable detection of respiratory depression with RRa.

Joe Kiani, Masimo CEO and Chairman of the Board, stated: "We are very proud to introduce the 2012 Radical-7 to the anesthesia community at the World Congress of Anaesthesiologists. In 2000, we 'wowed' the healthcare industry with the original Radical. We believe the industry will once again be 'wowed' by the new clinician-centric Radical-7 and what it can do to improve the process of care and ultimately, patient care."

The 2012 Radical-7 can be seen at the World Congress of Anaesthesiologists at Exhibit 64-65. Masimo also will be hosting a sold-out industry symposium, "Improved Patient Outcomes and Decreased Cost of Care with Masimo rainbow® Technology," on Monday, March 26. In addition, Masimo will be hosting educational seminars in Exhibit 64-65 throughout the meeting.

Masimo Pronto-7

Pronto-7 — with rainbow 4D^™ Technology — for noninvasive and quick spot checking of hemoglobin (SpHb^®), SpO₂, pulse rate, and perfusion index

A New Solution for Spot Checking

For the first time ever, technology in the Masimo Pronto-7 offers noninvasive and quick spot checking of hemoglobin (SpHb), SpO₂, pulse rate, and perfusion index, which may provide the following benefits:

CLINICIAN

• > Facilitates timely assessment

STAFF

• > Easy to use — reduces training time and improves efficiency
• > Requires no lab consumables or waste disposal

PATIENT

• > Enables immediate face-to-face counseling with clinician

It's As Easy As 1-2-3

Place sensor on finger

Press test button

Obtain results
Automatically saved — option to print,
e-mail, or manually record

SpHb Accuracy

In 3,519 comparisons of SpHb and invasive hemoglobin (tHb) measurements from a laboratory reference device, SpHb accuracy was as follows:¹

• > -0.06 g/dL bias
• > 0.82 g/dL at one standard deviation
• > Below 12 g/dL, 100% of SpHb readings were <2 g/dL of the laboratory tHb value
• > At or above 12 g/dL, 99% of SpHb readings were <2 g/dL of the laboratory tHb value

• ¹ Masimo FDA 510(k) Clearance Submission Data (Technical Bulletin, Accuracy of Noninvasive Spot-Checking of Total Hemoglobin with the Masimo Pronto-7).

Masimo Initiates Limited Release of First-ever Noninvasive and Continuous Hemoglobin Monitors

Irvine, California – September 15, 2008 – Masimo (NASDAQ: MASI), the inventor of Pulse CO-Oximetry and Measure-Through-Motion-and-Low-Perfusion pulse oximetry, today announced limited release of its noninvasive and continuous hemoglobin (SpHb™) and oxygen content (SpOC™) monitors, Radical-7 and Rad-87. Masimo also announced the FDA 510(k) clearance of its latest Rainbow family of adhesive sensors capable of noninvasively measuring total hemoglobin and oxygen content, along with oxygen saturation (SpO2), pulse rate, pleth variability index (PVI), and methemoglobin (SpMet®), for use with Masimo Rainbow SET-enabled devices.

The limited release of Masimo Radical-7 and Rad-87 Pulse CO-Oximeters with noninvasive and continuous total hemoglobin technology will allow select hospitals around the world to be the first to pioneer a breakthrough technology that may make it safer, faster, and easier for healthcare professionals to measure hemoglobin—without removing a drop of blood. Hospitals purchasing noninvasive hemoglobin devices and selected for the limited product release will work closely with Masimo to implement the technology in their facilities and provide data on its impact on patient care.

Masimo Announces Continuous Noninvasive Functional Hemodynamic Monitoring With Plethysmograph Variability Index (PVI)

Symposium presentation during the 2007 European Society of Anaesthesia Congress in Munich, Germany cites independent research showing the potential value of this new noninvasive diagnostic tool

Irvine, California June 20, 2007 - Masimo, the inventor of Pulse CO-Oximetry and Read-Through Motion and Low Perfusion pulse oximetry, reported that new independent studies presented at a symposium during the European Society of Anaesthesia in Munich, Germany last week indicated that Masimo's Plethysmograph Variability Index (PVI), a noninvasive measurement that quantifies changes in the plethysmographic waveform derived from pulse oximetry, can provide clinicians with a noninvasive way to monitor functional hemodynamics in their patients.

Clinicians who have evaluated PVI believe this technology will prove to be a valuable clinical tool with significant advantages over currently available indicators of changes in functional hemodynamics that are invasive, operator dependent, often inaccurate, and expensive. PVI displays a numeric representation of the changes to the pleth waveform on the pulse oximeter and allows clinicians to track and trend these changes over time as well as a Diagnostic Plethysmograph that maintains the morphology of the true pleth for clinicians to view.

In his presentation in Munich, Maxime Cannesson, MD from the Claude Bernard University and Louis Pradel Hospital in Lyon, France cited research he co-authored entitled Ability of a Novel Algorithm for Noninvasive Automatic Estimation of the Respiratory Variations in the Pulse Oximeter Waveform to Detect Changes in Ventricular Preload scheduled for publication in the journal Anesthesiology later this year that indicates Masimo's PVI method of quantifying changes in ventricular preload, and therefore the ability of the heart to pump adequate blood to the tissues, correlated well with invasive methods.1

Dr. Cannesson said the authors had demonstrated in an earlier study that a change in the beat to beat amplitude of the oximeter waveform of greater than 15% predicted whether a patient was able to adapt to fluid restoration with an appropriate physiological response.2

Dr. Cannesson said that it was his belief that "Pleth Variability Index can automatically and noninvasively detect changes in ventricular preload in mechanically ventilated patients in the operating room. PVI shows great promise for use in perioperative fluid optimization which will have both clinical and economical impact. Other clinical applications for PVI are in the areas of fluid depletion/restriction, mechanical ventilator settings/adjustments, detection of changes in myocardial contractility."

Other clinicians have concurred with these observations and feel that the ability of Masimo Rainbow SET oximeters to display PVI may provide them with a useful clinical data point in the management of their patients.

Dr. Mitchell Goldstein of Loma Linda University Children's Hospital said "Trending of PVI may be useful in monitoring critical care and surgical patients, both intraoperatively and postoperatively, for appropriate hydration and ventilation status."

Dr. Dan Redford of the University of Arizona, University Medical Center added "PVI may be useful in monitoring surgical patients, for appropriate intravascular volume status. For example, a rising PVI may indicate developing hypovolemia, and a falling PVI post-fluid resuscitation is evidence of an appropriate fluid responsiveness, and important measure in the critical care/OR environment."

About Masimo
Masimo develops innovative monitoring technologies that significantly improve patient care-helping solve "unsolvable" problems. In 1995, the company debuted Read-Through Motion and Low Perfusion pulse oximetry, known as SET and with it virtually eliminated false alarms and increased pulse oximetry's ability to detect life-threatening events. More than 100 independent clinical studies have confirmed that Masimo SET technology allows clinicians to accurately monitor blood oxygen saturation in critical care situations-establishing the technology as the "gold standard" pulse oximetry and substantially contributing to improved patient outcomes. In 2005 Masimo introduced Masimo Rainbow SET Pulse CO-Oximetry, which, for the first time, noninvasively monitors the level of carbon monoxide and methemoglobin in the blood, allowing early detection and treatment of potentially life-threatening conditions. Masimo, founded in 1989, has the mission of "Improving Patient Outcomes and Reducing Cost of Care by Taking Noninvasive Monitoring to New Sites and Applications." Additional information about Masimo and its products may be found at www.masimo.com.

1 "Ability of a Novel Algorithm for Noninvasive Automatic Estimation of the Respiratory Variations in the Pulse Oximeter Waveform to Detect Changes in Ventricular Preload", Maxime Cannesson, Bertrand Delannoy, Antoine Morand, Pascal Rosamel, Jean-Jacques Lehot. Anesthesiology 2007 (In Press).
2 "Relation Between Respiratory Variations in Pulse Oximetry Plethysmographic Waveform Amplitude and Arterial Pulse Pressure in Ventilated Patients", Maxime Cannesson, Cyril Besard, Pierre G. Durand, Julien Bohe, and Didier Jacques. Critical Care 2005.

Radical

Radical is the most advanced, yet flexible pulse oximeter in the world. In addition to being the most feature-packed, stand-alone pulse oximeter available, Radical can operate in two additional modes. The front module of Radical can be removed, creating a fully featured handheld pulse oximeter, ideal for transport. Radical can also be used to upgrade existing equipment through the sensor connector, thus not requiring additinal hardware or software upgrades to improve the performance of your current multiparameter monitor to Masimo SET.

* Masimo SET is the proven gold standard in reading through motion & low perfusion to reduce false alarms and detect true eventsThe Radical is a fully featured Standalone pulse oximeter
* The Radical is a fully featured Handheld pulse oximeter
* The Radical interfaces to validated multiparameter patient monitors to replace the existing conventional pulse oximetry with Masimo SET pulse oximetry.
* Unprecedented specificity and sensitivity. Essentially eliminates false alarms and detects virtually all true alarms.
* Accurate during most patient movement, including shivering, combativeness, neonatal movement, and seizures. Motion and Low Perfusion Study
* Accurate during low perfusion.
* Accurate during intense ambient light and resists electrocautery interference.

Oximeter sensors

Seamless Nellcor Alternative connects directly to your existing Nellcor patient cable.

Ambient Light Protection- recessed photodetector minimizes ambient light interference even in intense light situations.

Durable Construction- tear-resistant materials and an 18-inch cable pigtail with DB-9 connector.

Rad-57

Noninvasive Measurement of Methemoglobin, Carboxyhemoglobin, Oxyhemoglobin and Pulse Rate in seconds!

Masimo is proud to introduce the next breakthrough in noninvasive patient monitoring; Masimo Rainbow™ SET Pulse CO-Oximetry™. Rainbow technology combines the latest in system theory, adaptive signal processing and a revolutionary sensor that employs 7+ wavelengths of light to collect and analyze an extraordinarily rich stream of physiological data. Sophisticated processing of this data permits Rainbow SET’s unique ability to accurately measure carbon monoxide (SpCO™), methemoglobin (SpMet™) and potentially other future parameters.

Rad-57 Features:

* Revolutionary hardware and software analyzes 7+ wavelengths of light simultaneously to accurately measure Carboxyhemoglobin (SpCO) and Methemoglobin (SpMet) percent levels in the blood within seconds, noninvasively
* Designed for continuous or spot check applications
* User configurable power up default settings
* Four AA alkaline batteries deliver over 8 hours of continuous monitoring of SpCO, SpMet, SpO2, Pulse Rate and Perfusion Index
* Perfusion Index (PI) indicates arterial pulse signal strength and may be used as a diagnostic tool during low perfusion**
* Low Signal IQ® (SIQ) indicator highlights conditions of low signal quality
* FastSat® tracks rapid changes in arterial O2 with unmatched fidelity
* SmartTone™ beeps in sync with pulse, even under patient motion conditions
* Up to 72 hours of trending memory of SpCO, SpMet, SpO2, Pulse Rate and Perfusion Index
* Sensitivity options: APOD, Normal, and MAX
* Protective boot covers and carrying cases available in multiple colors